Acne is often present. Acne conglobata is a particularly severe form of acne that can develop during steroid abuse or even after the drug has been discontinued. Infections are a common side effect of steroid abuse because of needle sharing and unsanitary techniques used when injecting the drugs into the skin. These are similar risks to IV drug abusers with increased potential to acquire blood-borne infections such as hepatitis and HIV/AIDS . Skin abscesses may occur at injection sites and may spread to other organs of the body. Endocarditis or an infection of the heart valves is not uncommon.
Anabolic steroids are synthetic versions of hormones that human body produces naturally. Their main role is to assure increased physical performance in all sports and athletic pursuits. Steroidal compounds enhance stamina, strength, weight and size of muscles and may improve the energy levels during physical training. Oral and injectable steroids posses the ability to increase athletic performance, have a positive effect on red blood cells production and bones density. The steroids are used in accordance with requirement and needs of any athlete individually. There are special compounds which are not suitable for women and a series of anti-estrogen products which main role is to counter the eventual side effects of steroids use and to restore natural testosterone levels of the human body. These compounds nowadays became an important part of muscle building process among professional athletes and bodybuilders, as well as regular people, males and females that have the goal to become more attractive and exhibit good looks. Follow us on Twitter | Steroids Store - Pinterest .
The myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist, (17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), as well as by dihydrotestosterone (DHT). YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. These results suggest that the induction of Fst is important for the anabolic effect of YK11.