Coresatin Nonsteroidal Cream) is a topical skin cream, and as such, it must be applied as directed by the prescribing physician to the part of the skin that needs to be treated. Follow the directions provided by your physician. Generally speaking, adults treating psoriasis or other inflammatory skin conditions are instructed to apply it to the skin 3 to 6 times per day. Do not apply more of the cream than your physician tells you to. It is also important to note that the pediatric version of this cream should only be used to treat a child if a physician prescribes it for this purpose.