Women who go into labour before 37 weeks of pregnancy should be offered antibiotics to prevent a possible transmission of Group B Streptococcal (GBS), according to updated guidance published by the Royal College of Obstetricians and Gynaecologists (RCOG). The Green-top Guideline, co-authored by Professor Peter Brocklehurst at the University of Birmingham, provides guidance for obstetricians, midwives and neonatologists on the prevention of early-onset neonatal GBS.
For all the infants below the fifth percentile, newborn deaths by the 28th day of life did not differ significantly between the intervention group and the control group: 225 per thousand, compared to 232 per thousand. However, among all the infants in the study, more deaths at 28 days occurred among the intervention group than the control group: versus per thousand. Similarly, perinatal mortality — stillbirths and infant deaths in the first week of life — were also higher for the intervention group: 48 versus per thousand.