Methylprednisolone 4 mg steroid

A wide range of psychiatric reactions include affective disorders (such as irritable, euphoric, depressed and labile moods psychological dependence and suicidal thoughts), psychotic reactions (including mania, delusions, hallucinations and aggravation of schizophrenia), behavioural disturbance , irritability, anxiety, sleep disturbances, cognitive dysfunction including confusion and amnesia have been reported for all corticosteroids. Reactions are common and may occur in both adults and children. In adults, the frequency of severe reactions was estimated to be a 5-6%. Psychological effects have been reported on withdrawal of corticosteroids; the frequency is unknown

During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every 6 hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1 1/4 to 1 1/2 days following a single dose) and thus are recommended for alternate day therapy.

Dosage requirements of corticosteroids vary among individuals and the diseases being treated. In general, the lowest effective dose is used. The oral dose range is 2-60 mg daily depending on the disease. Depo-medrol doses are 10-80 mg injected into muscle every 1-2 weeks, and Solu-medrol doses are 10-250 mg intravenous or intramuscular injections up to 6 times daily. The initial dose should be adjusted based on response. Corticosteroids given in multiple doses throughout the day are more effective but also more toxic than the same total daily dose given once daily, or every other day.

In clinical studies, cyproterone was found to be far less potent and effective as an antiandrogen relative to CPA, likely in significant part due to its lack of concomitant antigonadotropic action. [3] Cyproterone was studied as a treatment for precocious puberty by Bierich (1970, 1971), but no significant improvement was observed. [18] In men, 100 mg/day cyproterone proved to be rather ineffective in treating acne , which was hypothesized to be related to its progonadotropic effects in males and counteraction of its antiandrogen activity. [3] [19] In women however, in whom the drug has no progonadotropic activity, 100–200 mg/day oral cyproterone was effective in reducing sebum production in all patients as early as 2–4 weeks following the start of treatment. [3] In contrast, topical cyproterone was far less effective and barely outperformed placebo . [3] In addition, another study showed disappointing results with 100 mg/day cyproterone for reducing sebum production in women with hyperandrogenism . [3] Similarly, the drug showed disappointing results in the treatment of hirsutism , with a distinct hair reduction occurring in only a limited percentage of cases. [3] In the same study, the reduction of acne was better, but clearly inferior to that produced by CPA, and only the improvement in seborrhea was regarded as satisfactory. [3] The addition of an oral contraceptive to cyproterone resulted in a somewhat better improvement in acne and seborrhea relative to cyproterone alone. [3] According to Jacobs (1979), “[cyproterone] proved to be without clinical value for reasons that cannot be discussed here.” [20] In any case, cyproterone has been well-tolerated by patients in dosages of up to 300 mg/day. [3]

Methylprednisolone 4 mg steroid

methylprednisolone 4 mg steroid

In clinical studies, cyproterone was found to be far less potent and effective as an antiandrogen relative to CPA, likely in significant part due to its lack of concomitant antigonadotropic action. [3] Cyproterone was studied as a treatment for precocious puberty by Bierich (1970, 1971), but no significant improvement was observed. [18] In men, 100 mg/day cyproterone proved to be rather ineffective in treating acne , which was hypothesized to be related to its progonadotropic effects in males and counteraction of its antiandrogen activity. [3] [19] In women however, in whom the drug has no progonadotropic activity, 100–200 mg/day oral cyproterone was effective in reducing sebum production in all patients as early as 2–4 weeks following the start of treatment. [3] In contrast, topical cyproterone was far less effective and barely outperformed placebo . [3] In addition, another study showed disappointing results with 100 mg/day cyproterone for reducing sebum production in women with hyperandrogenism . [3] Similarly, the drug showed disappointing results in the treatment of hirsutism , with a distinct hair reduction occurring in only a limited percentage of cases. [3] In the same study, the reduction of acne was better, but clearly inferior to that produced by CPA, and only the improvement in seborrhea was regarded as satisfactory. [3] The addition of an oral contraceptive to cyproterone resulted in a somewhat better improvement in acne and seborrhea relative to cyproterone alone. [3] According to Jacobs (1979), “[cyproterone] proved to be without clinical value for reasons that cannot be discussed here.” [20] In any case, cyproterone has been well-tolerated by patients in dosages of up to 300 mg/day. [3]

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