Yeast infections are treated with a pill that you swallow, or with a vaginal cream or vaginal suppository (a partially solid material that you insert into your vagina, where it dissolves and releases medicine). Your health care provider will explain to you what your choices are and if one is better than another for you. The pill is especially good if you don’t want to put cream inside of your vagina. Some anti-yeast vaginal creams are sold over-the-counter (without a prescription) in pharmacies. Other anti-yeast vaginal creams need a prescription. If you use a cream, then you should not use tampons during the treatment since it will absorb the medication and make it less effective.