Panel includes Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG by IFA with reflex to titer and immunoblot (Hu, Ri, Yo); amphiphysin antibody IgG; antibody IgG by IFA with reflex to titer; NDMA receptor antibody, IgG with reflex to titer; GAD antibody; VGKC antibody; aquaporin-4 receptor antibody; aquaporin-4 receptor antibody, IgG by IFA with reflex to titer; leucine-rich, glioma-inactivated protein 1 antibody, IgG with reflex to titer; contactin-associated protein-2 antibody, IgG with reflex to titer; VGCC antibody, acetylcholine receptor binding antibody with reflex to acetylcholine receptor modulating antibody; titin antibody and striated muscled antibody.
The mechanism of stimulating NMDA receptor is a specific agonist-binding to its NR2 subunits, and then a non-specific cation channel is opened, which can allow the passage of Ca 2+ and Na + into the cell and K + out of the cell. The excitatory postsynaptic potential (EPSP) produced by activation of an NMDA receptor also increases the concentration of Ca 2+ in the cell. The Ca 2+ can in turn function as a second messenger in various signaling pathways.     This process is modulated by a number of endogenous and exogenous compounds and plays a key role in a wide range of physiological (. memory) and pathological processes (. Excitotoxicity ).