Side effects of corticosteroids in cats

Symptoms of dystonia , prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.

And, exacerbating these two age-related erosive events, some catabolites of tryptophan can lead to the formation of mutagenic nitrosamines or the activation of an immunosuppressive receptor (which is usually triggered by toxicants such as xenobiotics), promoting carcinogenesis (Mezrich, et al., 2010; Chung & Gadupudi, 2011).

The consumption of a supplement of tryptophan will likely nurture or augment these disastrous age-associated disease states, by raising injurious tryptophan derivatives (particularly in the presence of a vitamin B6 deficiency, an insufficiency of stomach acid, a magnesium deficit, and a vitamin B3 deficiency).

Furthermore, tryptophan side effects in regards to greater mortality were shown in animal experiments (., Catrina, et al., 2001) using melatonin, whereas the study authors cautioned:

“[...] melatonin had a deleterious effect on the survival rate raising the question whether it is correct to assume that the hormone shows lack of adverse reactions.” [emphasis added]

In regard to serotonin's involvement in the promotion of higher mortality, one of its anti-longevity effects is conceivably the reabsorption of phosphate (a pro-inflammatory chemical) by the kidneys since klotho, an anti-aging protein, facilitates the excretion of phosphate from the kidneys (Peat, Nov. 2012).

Since tryptophan, serotonin, and melatonin meddle with basic energy production in cells, and since metabolic efficiency and functionality decreases proportionally with aging (Fannin, et al., 1999; O'Toole, et al., 2010) due to various factors, it seems coherent in biological terms that these substances are less prevalent, thus less “essential” or needed, in older people, as a further decrease of an already suboptimal general metabolic working order will aggravate physiological function systematically, increase the risk for disease (as exemplified and foreshadowed with tryptophan side effects), promote the aging process, and explains the increased mortality related to the administration of these substances.

Several tryptophan side effects, such as tryptophan's carcinogenic activities, the deterioration of metabolic energy function, and the promotion of hypertension, can rather readily account for a greater death rate.

Side effects of corticosteroids in cats

side effects of corticosteroids in cats

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