long-acting beta-2 adrenergic agonists (LABA) incr. risk of asthma-related death; data from large placebo-controlled US study showed incr. in asthma-related deaths in pts receiving salmeterol plus usual asthma tx, results considered LABA class effect; inadequate data to determine if concurrent inhaled corticosteroids or other long-term asthma control tx mitigates incr. risk of asthma-related death from LABA; LABA use may incr. risk of asthma-related hospitalization in pediatric and adolescent pts; use only for asthma pts not controlled on long-term asthma control tx, such as inhaled corticosteroid, or whose dz severity requires tx w/ both corticosteroid and LABA; once asthma control is achieved and maintained, assess pt at regular intervals and step down tx, such as D/C corticosteroid/LABA combo, if possible w/o loss of asthma control; maintain pt on long-term asthma control tx such as inhaled corticosteroid; do not use corticosteroid/LABA combo if asthma adequately controlled on low-or medium-dose inhaled corticosteroids
Alphaviron (mesterolone) is basically an orally active DHT (Dihydrotestosterone) preparation .For comparision, we can think of some other orally prepared DHT compounds like Winstrol, Anavar, etc& Those both act very similarly in mechanism to Alphaviron, but a more accurate way to think of this compound is as something like “Oral Masteron.” As Im sure you noticed, their anabolic/androgenic ratio is very , DHT is 3 to 4 times as androgenic as testosterone and is, of course, incapable of forming estrogen. Also, Alphaviron is quite unique in that a simple look at its 4-ring structure will show us that it is not going to be too liver toxic, since it is not c17-Alpha-Alkylated, as many orals are& this modification (lacking in Alphaviron) makes drugs more liver toxic. Alphaviron has a 1-metyhl group added, instead. Looks pretty great on paper, right? Well, as usual, things tend to look better on paper than they do in the body. Your body has a negative feedback loop which prevents your body from having too much DHT floating around(if youve been paying attention up to now from reading my other stuff, you already know this). An excess of DHT will eventually be changed into another (largely not anabolic) of course, being a DHT-based compound, Alphaviron isnt going to be great for female athletes to use. Virilization (development of male sexual characteristics) is going to be a concern for women daring enough to try this stuff. My advice is that there is much better, safer compounds for female athletes and bodybuilders to use..