Steroid 5 alpha-reductase 3

Pumpkin seed oil has also been proven to inhibit the production of 5-alpha-reductase. Pumpkin seeds contain not one but two DHT blockers. The first is beta-sitosterol, a phytosterol, which is structurally like cholesterol. The other is a steroid, delta-7-sterine. A 2014 Chinese study evaluated the effect of a daily dose of 400mg of pumpkin seed oil on 38 men with AGA. A randomized equal number of men received a placebo. After 24 weeks, scientists discovered a 40% mean increase in hair count in the group receiving the pumpkin seed oil as compared to the placebo group.

Dutasteride, however, is a so-called dual inhibitor with both 5α-R1 and 5α-R2 inhibition. IC50 for 5α-R1 is 7 nM but 6 nM for 5α-R2. As mentioned above, it reduces DHT > 90% overall, or precisely % and for intraprostatic DHT the reduction is 97-99%. Dutasteride has also been found to inhibit 5α-R3, in vitro, with IC50= nM. [18] The 2,5-difluorophenyl side chain on the D-ring of the compound shows significant lipophilic features and as increased lipophilicity enhances the potency of the compounds binding at pocket site, its potency is much greater than of finasteride. [25]

The disorder has been found in blacks, whites, American Indians, and Latin Americans, as well as in families from Malta, Jordan, and Pakistan. Imperato-McGinley et al. (1991) described a cluster of male pseudohermaphrodites in the Simbari Anga linguistic group in the Eastern Highlands of Papua New Guinea. Their studies revealed a phenotypic and biochemical profile similar to that in patients studied in the Dominican Republic, except for a greater abundance of facial and body hair. DHT is responsible for masculinization of the external genitalia of the fetus and for masculinization at puberty. The virilization at puberty in PPSH may be related to the facts that the reductase is not completely absent and that low levels of DHT are found in plasma.

Steroid 5 alpha-reductase 3

steroid 5 alpha-reductase 3

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