Steroids acute liver failure

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The answer is that liver damage from acetaminophen occurs when the glutathione pathway is overwhelmed by too much of acetaminophen's metabolite, NAPQI. Then, this toxic compound accumulates in the liver and causes the damage. Furthermore, alcohol and certain medications such as phenobarbital, phenytoin ( Dilantin ), or carbamazepine ( Tegretol ) (anti- seizure medications) or isoniazid (INH, Nydrazid, Laniazid) - (anti- tuberculosis drug) can significantly increase the damage. They do this by making the cytochrome P-450 system in the liver more active. This increased P-450 activity, as you might expect, results in an increased formation of NAPQI from the acetaminophen. Additionally, chronic alcohol use, as well as the fasting state or poor nutrition , can each deplete the liver's glutathione. So, alcohol both increases the toxic compound and decreases the detoxifying material. Accordingly, the bottom line in an acetaminophen overdose is that when the amount of NAPQI is too much for the available glutathione to detoxify, liver damage occurs.

Q. What is Liver Cirrhosis? I read that alcohol can lead to liver cirrhosis. What does cirrhosis mean? A. The word "cirrhosis" is a neologism that derives from Greek kirrhos, meaning "orange-yellow". In this condition, the liver appears yellow in pathology from all the tissue changes and damage caused to it. Cirrhosis has many possible causes. Sometimes more than one cause is present in the same patient. In the Western World, chronic alcoholism and hepatitis C are the most common causes. The sick liver gradually loses its function, therefore leading to end stage liver disease that ultimately requires liver transplant.

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  • Citation tools Download this article to citation manager McPherson Stuart , Lucey Michael R , Moriarty Kieran J . Decompensated alcohol related liver disease: acute management BMJ 2016; 352 :i124
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    Steroids acute liver failure

    steroids acute liver failure

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  • Citation tools Download this article to citation manager McPherson Stuart , Lucey Michael R , Moriarty Kieran J . Decompensated alcohol related liver disease: acute management BMJ 2016; 352 :i124
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